Publications

Here are some of the key research outputs of the lab. Please contact me if you would like a .pdf of any outputs.

Smith, William PJ, and Elisa T. Granato. “Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency.” Microbiology 171.8 (2025): 001600.

Smith, William PJ, et al. “Evolution: the beating heart of AMR.” UK Parliament Committee of Public Accounts, Thirtieth Report of Session 2024–25, AR0020, March 2025

Smith, William PJ, et al. “Multiplicity of type 6 secretion system toxins limits the evolution of resistance.” Proceedings of the National Academy of Sciences 122.2 (2025): e2416700122.

Booth, Sean C*., William PJ Smith*, and Kevin R. Foster. “The evolution of short-and long-range weapons for bacterial competition.” Nature Ecology & Evolution 7.12 (2023): 2080-2091.

Smith, William PJ, et al. “Bacterial defences: mechanisms, evolution and antimicrobial resistance.” Nature Reviews Microbiology 21.8 (2023): 519-534.

Granato, Elisa T.*, William PJ Smith*, and Kevin R. Foster. “Collective protection against the type VI secretion system in bacteria.” The ISME journal 17.7 (2023): 1052-1062.

Krishna Kumar, Ravinash, et al. “Droplet printing reveals the importance of micron-scale structure for bacterial ecology.” Nature communications 12.1 (2021): 857.

Smith, William PJ, et al. “The evolution of tit-for-tat in bacteria via the type VI secretion system.” Nature communications 11.1 (2020): 5395.

Smith, William PJ*, et al. “The evolution of the type VI secretion system as a disintegration weapon.” PLoS biology 18.5 (2020): e3000720.

Booth, Sean C.*, and William PJ Smith*. “Light sheets unveil host-microorganism interactions.” Nature Reviews Microbiology 18.2 (2020): 65-66.

Frost, Isabel, et al. “Cooperation, competition and antibiotic resistance in bacterial colonies.” The ISME journal 12.6 (2018): 1582-1593.

Smith, William PJ, et al. “Cell morphology drives spatial patterning in microbial communities.” Proceedings of the National Academy of Sciences 114.3 (2017): E280-E286.

Doye, Jonathan PK, et al. “Coarse-graining DNA for simulations of DNA nanotechnology.” Physical Chemistry Chemical Physics 15.47 (2013): 20395-20414.

The Smith Lab

The Smith lab is located in the Michael Smith building on the University of Manchester campus in Manchester, UK. We are part of the School of Biological Sciences and Division of Evolution, Infection, and Genomics (EIGEN). The Smith lab is an activate member of the Microbial Evolution Research at Manchester (MERMan) group, a collective of 15 PIs and >60 research staff.

Contact: william.smith-4@manchester.ac.uk